李光华,医学博士,教授,博士研究生导师,生理学学科带头人,中国生理科学会常务理事。主要从事钟基因与心血管内皮细胞功能变化的机制研究。多次获得学校“优秀教师”、“师德标兵”、“优秀研究生指导教师”等荣誉称号。主持国家自然科学基金4项、省部级科研项目10余项,共发表学术论文120余篇。获宁夏科技成果三等奖2项、宁夏医学科学技术奖三等奖3项、自治区科技优秀论文一等奖2项、三等奖4项。主编【生物钟与子午流注】学术专著,以及【医学生理学】与【人体生理学实验指导】等教材。
研究方向:职业应激与健康
联系方式:
地址:宁夏医科大学基础医学院
电话:0951-6980976
邮箱:ghlee0404@163.com
主要科研项目:
1. 宁夏回族自治区重点研发计划项目(2024BBF01004),枸杞子干预/改善帕金森病与抑郁症的作用及其产品研发(2024/07-2027/06),主持
2. 宁夏自然科学基金重点项目(2021AAC02015),间断性热暴露下BMAL1通过AMPK/mTOR/ULK1调控自发性高血压大鼠血管内皮自噬及凋亡的分子机制研究(2021/05-2024/05),主持
3. 国家自然科学基金项目(82060050),间断性热暴露下钟基因调控高血压大鼠细胞周期蛋白及自噬的作用研究(2021/01.-2024/12.),主持
4. 国家自然科学基金项目(81760055),钟基因Per2在调节固定时间热暴露大鼠胸主动脉血管反应性变化中的作用及机制研究(2018/01-2021/12),主持
代表性论文:
1. Ruoyu Gou, Xiaoyu Chang, Danni Dou, Xin Meng, Ling Hou, Lingqin Zhu, Wei Tuo and Guanghua Li. Association of Cardiovascular health with COPD (NHANES 2007-2020): Mediating Effects of lean body mass. Frontiers in Endocrinology. PUBLISHED 04 April 2025(通讯作者)
2. Lunjing Liu, Yu Fu, Chengli Zhang, Jingyan Lin, Huiyi Yang, Wenjie Wu, Jingru Wang, Jiang Xiao, Yideng Jiang, Yuhui Liao, Guanghua Li. Tripropylamine facilitates efficient preparation of flower-like nanozyme for rapid and sensitive Mpox point-of-care testing [J]. Microchemical Journal, 2025: 113337. (通讯作者)
3. Le Mu, Shujing Xue, Wei Tuo, Xiaomin Wu, Ling Hou, Guanghua Li. Nec-1 regulates phenotypic transformation of heat stroke-induced vascular smooth muscle cells by inhibiting RIPK1 Le Mu, Shuji, International Journal of Hyperthermia, 2025, Vol. 42, no. 1, 2463477(通讯作者)
4. Ruoyu Gou, Lili Chen, Zeyi Cheng, Jiawei Cun,Guanghua Li. 5Association of dietary intake of saturated fatty acids with obstructive sleep apnea: mediating effects of Life’s Crucial 9. Front. Nutr. , 17 February 2025, Sec. Clinical Nutrition. Volume 12 - 2025 (通讯作者)
5. Mi Tian, Hongting Cao, Haoxuan Gao, Lingqin Zhu, Yang Wu, Guanghua Li.Rotenone-induced cell apoptosis via endoplasmic reticulum stress and PERK-eIF2α-CHOP signalling pathways in TM3 cells. Ecotoxicology and Environmental Safety Volume 284, 1 October 2024, 116972(通讯作者)
6. Xiaoyu Chang, Zeyuan Li, Mi Tian, Ziwei Deng, Lingqin Zhu, Guanghua Li. Rotenone activates the LKB1-AMPK-ULK1 signaling pathway to induce autophagy and apoptosis in rat thoracic aortic endothelial cells. BMC Pharmacology and Toxicology (2024) 25:33(通讯作者)
7. Ruoyu Gou, Danni Dou, Mi Tian, Xiaoyu Chang, Yonggang Zhao, Xin Meng, Guanghua Li. Association between triglyceride glucose index and hyperuricemia: a new evidence from China and the United States. Front Endocrinol (Lausanne) . 2024 Jul 1:15:1403858. (通讯作者)
8. Chunli Yang, Ziwei Deng, Qihang Zeng, Xiaoyu Chang, Xiaomin Wu, Guanghua Li. BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of rats induced by intermittent heat stress through the AMPK/ mTOR/ULK1 pathway. Biochemical and Biophysical Research Communications 661 (2023) 34e41(通讯作者)
9. Dandan Chen, Yao Geng, Ziwei Deng, Peiling Li, Shujing Xue, Tao Xu, and Guanghua Li. Inhibition of TLR4 Alleviates Heat Stroke-Induced Cardiomyocyte Injury by Down-Regulating Inflammation and Ferroptosis. Molecules. 2023, 28(5).(通讯作者)
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