王发选，医学博士、教授、博士研究生导师、宁夏医科大学青年学术骨干。宁夏医科大学公共卫生与管理学院职业卫生与环境卫生学系副主任。自治区级一流课程《职业卫生与职业医学》负责人，2021年入选宁夏回族自治区青年拔尖人才。

从事职业卫生与职业医学教育教学工作16年，承担本科生及研究生《职业卫生与职业医学》《医学科研方法》《循证医学》《图片处理与论文排版》《职业环境危害因素监测与评价》等多门课程教学任务，受到学生一致好评。

科研方面主要从事矽肺发病及纤维化分子机制研究，主持国家自然科学基金项目3项。主持宁夏自然科学基金项目2项，教育厅优秀青年教师培育基金项目2项。参与完成科技部重大专项和多项大型国际合作课题。发表高水平科研论文四十余篇。

一、主持或者参与的科研项目

（1）国家自然科学基金地区项目，lncRNA MRAK050699、BC167061竞争结合miR-204-3P靶向TGFBR1调控EMT过程对矽肺纤维化的影响研究 2021.1-2024.12，35万元，主持；

（2）国家自然科学基金地区项目，LncRNA通过调控TGF/smad3信号通路在矽肺发生和纤维化中的调控作用研究，2017.1-2020.12，41万元，主持；

（3）国家自然科学基金青年基金项目，miR-146a和miR-181b在矽肺发生和纤维化中的调节作用研究，2013.1-2015.12，23万元，主持；

（4）宁夏自然科学基金重点项目，LncRNA MRAK052509 吸附miR-204-3p调控TGF-βRI影响矽肺纤维化的机制研究，30万元，主持；

（5）宁夏重点研发计划重点项目，基于遗传、环境复杂网络的宁夏地区心脑血管疾病多维预测及防控策略研究，2021BEG02026,2021.06-2024.05 185万元，子课题负责人；

（6）国家重点研发计划“精准医学”西北区域自然人群队列研究 宁夏回汉队列建设及膳食结构与健康关系研究（2017YFC0907204）、2017/10-2020/12、269万元，主要负责人。

二、代表性论文：

（1）Faxuan W., Qin Z., Dinglun Z., Tao Z., Xiaohui R., Liqiang Z., Yajia L. Altered microRNAs expression profiling in experimental silicosis rats [J]. The Journal of toxicological sciences, 2012, 37(6): 1207.

（2）Zhang Yang, Wang Faxuan, Lan Yajia, Zhou Dinglun, Ren Xiaohui, Zhao Liqiang, Zhang Qin. Roles of microRNA-146a and microRNA-181b in regulating the secretionof tumor necrosis factor-α and interleukin-1β in silicon dioxide-induced NR8383rat macrophages [J]. Molecular medicine reports, 2015, 12(4): 5587-5593.

（3）Zhang Yang, Wang Faxuan, Zhou Dingzi, Ren Xiaohui, Zhou Dinglun, Gao Xiaosi, Lan Yajia, Zhang Qin, Xie Xiaoqi. Genome-wide analysis of aberrantly expressed microRNAs in bronchoalveolar lavage fluid from patients with silicosis [J]. Industrial Health, 2016, 54(4): 361-369.

(4)Wang Faxuan, Tian Di, Zhao Yi, Li Jiangping, Chen Xiyuan, Zhang Yuhong. High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function [J]. Evidence-Based Complementary and Alternative Medicine, 2021, 2021: 6615595.

(5)Neal Bruce, Wu Yangfeng, Feng Xiangxian, Zhang Ruijuan, Zhang Yuhong, Shi Jingpu, Zhang Jianxin, Tian Maoyi, Huang Liping, Li Zhifang, Yu Yan, Zhao Yi, Zhou Bo, Sun Jixin, Liu Yishu, Yin Xuejun, Hao Zhixin, Yu Jie, Li Ka-Chun, Zhang Xinyi, Duan Peifen, Wang Faxuan, Ma Bing, Shi Weiwei, Di Tanna Gian Luca, Stepien Sandrine, Shan Sana, Pearson Sallie-Anne, Li Nicole, Yan Lijing L., Labarthe Darwin, Elliott Paul. Effect of Salt Substitution on Cardiovascular Events and Death [J]. New England Journal of Medicine, 2021, 385(12): 1067-1077.

(6)Wang Faxuan, Wang Binxia, Chen Xiyuan, Liu Wanlu, Wang Guoqi, Li Xiaoxia, Liu Xiuying, Li Nan, Zhang Jiaxing, Yin Ting, Jing Jinyun, Chang Xiaoyu, Jin Yanan, Zhang Yuhong, Zhao Yi. Association Between Blood Pressure and Branched-Chain/Aromatic Amino Acid Excretion Rate in 24-Hour Urine Samples from Elderly Hypertension Patients [J]. Diabetes Metab Syndr Obes, 2021, 14: 3965-3973.

(7)Zhu J, Wang F, Feng X, Li B, Ma L, Zhang J. Family with sequence similarity 13 member A mediates TGF-β1-induced EMT in small airway epithelium of patients with chronic obstructive pulmonary disease. Respir Res. 2021 Jul 1;22(1):192. doi: 10.1186/s12931-021-01783-z. PMID: 34210319; PMCID: PMC8247231.

(8) Wang F. X., Gao F. Y., Liu X., Chen X. Y., Tian D., Tian X. Y., Jiao Z. M., Hou P. Y. Long non-coding RNA expression in silicosis and MRAK050699 function in epithelial-mesenchymal transition [J]. Human & experimental toxicology, 2021, 40(12_suppl): S763-s774.

(9) Tian D., Chen X., Hou P., Zhao Y., Zhao Y., Zhang Y., Li J., Zhang Y., Wang F. Effects of exposure to fine particulate matter on the decline of lung function in rural areas in northwestern China [J]. Environmental science and pollution research international, 2022, 29(10): 14903-14913

(10) Hou Pengyi, Pi Yangyang, Jiao Ziming, et al. Association of Body Composition with Pulmonary Function in Ningxia: The China Northwest Cohort, 2022, 15:3244-3254.