强媛媛，女，1985年7月出生，研究生学历，理学博士，副教授，硕士生导师。2018年7月获中山大学分子医学博士学位，2018年9月至今为宁夏颅脑疾病重点实验室——国家重点实验室培育基地专职科研人员，宁夏医科大学生物化学与分子生物学系教师，中国肿瘤与微环境学会会员。主要从事肿瘤复发转移分子机制研究，癫痫与肠道微环境及抗癫痫药物的机制研究等方面的科研工作，主持参与国家级、省部级、校级项目5项，在国内外期刊发表论文20余篇，指导一名本科毕业生获优秀毕业生称号，指导本科生参加国家级大学生实验设计大赛获优秀奖及“厚生杯”获校级优秀奖，指导一名研究生获国家奖学金。

研究方向简介：

研究方向1：癫痫与肠道微环境的相关性

研究方向2：抗癫痫药物的机制研究

在研项目：

1. ADAP2在肾透明细胞癌中的功能及机制研究

2. 不良预后因素ADAP2通过EMT促进肾透明细胞癌恶性行为的机制研究

个人代表作：

1. Qiang YY, Li CZ#, Sun R, Zheng LS, Peng LX, Yang JP, Meng DF, Lang YH, Mei Y, Xie P, Xu L, Cao Y, Wei WW, Cao L, Hu H, Yang Q, Luo DH, Liang YY, Huang BJ, Qian CN*. Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling, Journal of experiment and clinical cancer research, 2018 Feb 20;37(1):34.

2. Yuanyuan Qiang, Jianguo Niu, Yun Wu, Zhao Di, et al. . Discovery of a novel cysteine framework XXIV conotoxin from Conus striatus, S24a, with potential analgesic activity International Journal of Peptide Research and Therapeutics, (published online 7th, september, 2020) 27, 615–625 (2021).

3. Yuanyuan Qiang, Yun Wu, Di Zhao, Boyao Zha, Feng Wang, et.al. Discovery and Characterization of the Novel Conotoxin Lv1d from Conus lividus that Presents Analgesic Activity. Toxicon. 2021 Apr 30;194:70-78.

4. Peng XS#, Yang JP#, Qiang YY#,Sun R, Cao Y, Zheng LS, et al. PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling. Molecular cancer research : MCR. 2020;18(6):903-12.

5. Wu Y#, Qiang Y#,Cao K, Zhang W, Zhang G. Inhibitory effect of the antimicrobial peptide BLP-7 against Propionibacterium acnes and its anti-inflammatory effect on acne vulgaris. Toxicon : official journal of the International Society on Toxinology. 2020;184:109-15.

6. Wu Y#, Qiang Y#, Zhang G, Zhou M. Acute toxicity and micronucleus test of conotoxin lt14a in mice. Basic Clin Pharmacol Toxicol. 2021 Mar

7. Xu L, Huang TJ, Hu H, Wang MY, Shi SM, Yang Q, Lin F, Qiang YY, Mei Y, Lang YH, Li CZ, Peng LX, Zheng LS, Huang JL, Li XJ, Zhang SJ, Qian CN*, Huang BJ*. The developmental transcription factor IRF6 attenuates ABCG2 gene expression and distinctively reverses stemness phenotype in nasopharyngeal carcinoma, Cancer Lett, 2018 Sep 1;431:230-243

8. Xie P, Yang JP, Cao Y, Peng LX, Zheng LS, Sun R, Meng DF, Wang MY；Mei Y；Qiang YY, Cao L, Xiang YQ, Luo DH, Yun JP, Huang BJ, Jia LJ, Qian CN*；Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target，Cell Death Dis，2017 Jun 1;8(6):e2834.

9. Meng DF, Xie P, Peng LX, Sun R, Luo DH, Chen QY, Lv X, Wang L, Chen MY, Mai HQ, Guo L, Guo X, Zheng LS, Cao L, Yang JP, Wang MY, Mei Y, Qiang YY, Zhang ZM, Yun JP, Huang BJ, Qian CN*. CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling, J Exp Clin Cancer Res, 2017 Jan 28;36(1):21.

10. Yang JP, Liao YD, Mai DM, Xie P, Qiang YY, Zheng LS, Wang MY, Mei Y, Meng DF, Xu L, Cao L, Yang Q, Yang XX, Wang WB, Peng LX, Huang BJ, Qian CN*. Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis, Angiogenesis, 2016 Apr;19(2):191-200.

11. Mei Y, Yang JP, Lang YH, Peng LX, Yang MM, Liu Q, Meng DF, Zheng LS, Qiang YY, Xu L, et al. Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression. Cell Cycle. 2018;17(8):963-973

12. Hu H, Xu L, Chen Y, Luo SJ, Wu YZ, Xu SH, Liu MT, Lin F, Mei Y, Yang Q, Qiang YY, Lin YW, Deng YJ, Lin T, Sha YQ, Huang BJ, Zhang SJ. The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis is Hepatocellular Carcinoma. J Cancer. 2019;10(4):957-967

13. Meng DF, Sun R, Peng LX, Huang YS, Yang Q, Luo DH, Hu WH, Xie FY, Luo W, Zhao C, Guo L, Mai HQ, Chen MY, Xie P, Zheng LS, Yang JP, Mei Y, Qiang YY, Xu L, Li CZ, Huang BJ, Qian CN, Sun R. A comparison of weekly versus 3-weekly cisplatin during concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma using intensity modulated radiation therapy: a matched study. J Cancer. 2018 Jan 1;9(1):92-99.

14. WuY; Wang Lei; Zhou Maojun; You Yuwen; Zhu Xiaoyan; Qiang Yuanyuan; Qin Mengying; Luo Shaonan; Ren Zhenghua;*Xu Anlong，Molecular Evolution and Diversity of Conus Peptide Toxins, as Revealed by Gene Structure and Intron Sequence Analyses.PLos One, 8(12), 2013/12/13.

15. Wang L, Tang W, Wang X, Chen Y, Wu Y, Qiang Y, Feng Y, Ren Z, Chen S，Xu A. PPIase is associated with the diversity of conotoxins from cone snail venom glands .Biochimie,2015/05

16. 王磊 ; 曾夏芸; 强媛媛; 任政华.芋螺毒素lt1c的重组表达及镇痛功能中.山大学学报(自然科学版), 2018, (02): 137-142

17. 王磊 ; 吴赟; 任政华; 强媛媛. T-超家族芋螺毒素S10a的制备及功能研究.中国海洋药物, 2017, (03): 89-93

专利：

1. 中国南海疣镐芋螺神经毒素及其编码序列和用途 201010620115.22（已授权）

2. 中国南海线纹芋螺毒素s21a的制备及应用201010620135.X（已授权）

联系方式：qiangyy@nxmu.edu.cn